Miscarriage Pregnancy and PGD Method
Miscarriage Pregnancy and PGD Method
It can be recommended for the risk of miscarriage (PGD), which shows a plus with the age of the expectant mother. By applying the PGD method, both the chance of pregnancy can be increased and the risk of miscarriage in the pregnancy obtained can be reduced.
The increased risk of miscarriage in pregnancy with increasing age can be explained by the risk of genetic disorders. With the age of the expectant mother, the number of eggs decreases, the quality of the eggs deteriorates, and in addition to these, the risk of genetic abnormalities in the eggs may increase.
Considering the age factor of miscarriage risk in pregnancy, the current risk of miscarriage in natural pregnancy obtained under the age of 35 is around 15 percent, while this rate can go up to 40-35% in pregnancies after 40 years.
Recurrent miscarriage, by definition, is defined as two or more miscarriages that occur before the 20th week of pregnancy. Scientific data shows that 3% of miscarriages in the first 80 months are due to a genetic problem in the baby. The genetic problem is caused by a momentary error that occurs when the sperm and the egg are merging, and this error usually does not recur in subsequent pregnancies. But if the miscarriage is recurrent, that is, if there have been 2 or more pregnancy losses in a row, the situation changes. In such a case, recurrent miscarriage (habitual abortion) is diagnosed and the factors that cause it need to be investigated. Genetic factors are the most important cause of miscarriage. As a result of the studies, it was understood that many of the recurrent miscarriages were due to chromosome (genetic) disorders. In cases of recurrent miscarriage due to genetic factors or in patients whose source cannot be found, it is recommended that IVF treatment and embryos are selected by preimplantation genetic diagnosis method, genetically screened and the healthiest embryo is transferred to the uterus.
How is PGD Done?
With the PGD method, which can be applied as part of the IVF process, the chromosome disorders that may be in the baby to be born are detected and the abnormal ones are eliminated and normal (healthy) embryos are transferred to the uterus. After the classical IVF steps are performed, the embryo is genetically examined before transferring.
PGD can be done by 3 methods.
Day 3 embryo biopsy
Day 5 embryo biopsy
Polar body biopsy